Kingdom of Knuffel

Does it plays in its own world or in reality? Like todays times?

I have to admit that I am not aware if it is on any steaming platform... I just have the DVDs >.<

But it's not what Nikki suggested (I don't know that one ^^°)

It is settled in it's own universe!

Is it some adventure they have to go through, like searching for a cure, fighting a villain?

Yes! They are on there way exploring and try to find the main characters mother.

Is the main character male or female?

Female. Although there is a male "co-main character" ^^°

But it isnt one about an orphanage, right?

An orphanage is featured at the beginning of the story, but is not the main part of it.

Guess into the blue.
Fruits basket?
Made in abyss?

which year came this anime out